Name: | Exenatide |
---|---|
Item Code: | HG016 |
CAS Number: | 141758-74-9 |
Other name: | Exenatide |
Molecular formula: | C184H282N50O60S |
Molecular mass: | 4186.63 |
Sequence: | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
Purity: | >98% |
Main usage: | Diabetes II |
Product Description
Exenatide, a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.
【Test】 | 【Specifications】 |
Appearance | White powder |
Solubility | Very soluble in water (>1mg/ml) |
Identification By HPLC | Retention time is same with the reference substance |
Molecular Ion Mass | 4186.6±1 |
Amino Acid Composition | ±10% |
Purity (HPLC) : | NLT 98.0 % |
Related Substances(HPLC) | Total impurities <2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | <12.0 % |
Water Content(Karl Fischer) : | ≦5 % |
Peptide Content : | NLT 80% |
Residual Solvents(Acetonitrile) | ≦0.041% |
Bacterial Endotoxins : | ≦5EU/mg |