Name: | Linaclotide |
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Item Code: | HG035 |
CAS Number: | 851199-59-2 |
Other name: | Linaclotide |
Molecular formula: | C59H79N15O21S6 |
Molecular mass: | 1526.8 |
Sequence: | H-Cys(1)-Cys(2)-Glu-Tyr-Cys(3)-Cys(1)-Asn-Pro-Ala-Cys(2)-Thr-Gly-Cys(3)-Tyr-OH |
Purity: | >98% |
Main usage: | treatment of constipated irritable bowel syndrome (IBS-C) and chronic constipation. |
Product Description
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipated irritable bowel syndrome (IBS-C) and chronic constipation.
【Test】 | 【Specifications】 |
Appearance | White powder |
Solubility | Very soluble in water (>1mg/ml) |
Identification By HPLC | Retention time is same with the reference substance |
Molecular Ion Mass | 1526.8±1 |
Amino Acid Composition | ±10% |
Purity (HPLC) : | NLT 98.0 % |
Related Substances(HPLC) | Total impurities <2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | <12.0 % |
Water Content(Karl Fischer) : | ≦8.0 % |
Peptide Content : | NLT 80% |
Residual Solvents(Acetonitrile) | ≦0.041% |
Assay | 95.0~105.0% |
Bacterial Endotoxins : | ≦5EU/mg |
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