Name: | Pasireotide |
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Item Code: | HG061 |
CAS Number: | 396091-73-9 |
Other name: | Signifor |
Molecular formula: | C58H66N10O9 |
Molecular mass: | 1047.2 |
Sequence: | cyclo[Hyp(Unk)-Phg-D-Trp-Lys-Tyr(Bn)-Phe] |
Purity: | >98% |
Main usage: | Cushing’s disease |
Product Description
Pasireotide is a synthetic polypeptide analogue of somatostatin that resembles the native hormone in its ability to suppress levels and activity of growth hormone, insulin, glucagon and many other gastrointestinal peptides. Because its half-life is longer than somatostatin, pasireotide can be used clinically to treat neuroendocrine pituitary tumors that secrete excessive amounts of growth hormone causing acromegaly, or adrenocorticotropic hormone (ACTH) causing Cushing disease. Pasireotide has many side effects including suppression of gall bladder contractility and bile production, and maintenance therapy can cause cholelithiasis and accompanying elevations in serum enzymes and bilirubin.
【Test】 | 【Specifications】 |
Appearance | White powder |
Solubility | soluble in water |
Identification By HPLC | Retention time is same with the reference substance |
Molecular Ion Mass | 1047.2 ±1 |
Amino Acid Composition | ±10% |
Purity (HPLC) : | ≥98.0 % |
Related Substances(HPLC) | Total impurities <2.0% Single impurities<1.0% |
Water Content(Karl Fischer) : | ≦8% |
Acetic acid Content : | ≦12% |
Residual Solvents(Acetonitrile) | ≦0.041% |
Assay(By Anhydrous,Acetic Acid-free) | 95.0~105.0% |